So, if we define reagents reasonably, potion brewing and spellcraft should progress from that. Potions that do not rely simply on the natural effect of their contents alone, but instead hold a spell effect will require a specific gem dust to seal in the magic until the potion is consumed.
So, a potion of healing derived from ginseng root extract alone, would have a shelf life, but it would not require any spellcasting skill or gem dust to create. An elixir of firebreath would.
A couple of definitions.
Potion: any combination of liquids or suspended reagents not requiring spellcasting to create. One uses potion-making skill to create potions.
Elixir: any combination of liquids or suspended reagents that require spellcasting skill to create and that usually have a spell-like effect when consumed. One uses Alchemy skill to create elixirs.
Alchemy differs from potion-making in that magical ingredients or spell-casting is required to produce the desired elixir (or salve, etc).
Potion-making skill would involve knowing how to prepare raw ingredients to the finished product.
Herbology skill would help one locate the raw plant ingredients in the wild.
Potions (and scrolls, spell tokens, etc) can be used by spellcasters as a platform for larger spells if they have the skill.
Elemental Spellcraft derives from the framework of potions and their raw materials. A witch at her caldron is much more dangerous than the witch alone.
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